How do genetics affect my risk for Alzheimer's disease?

Dr. Gary Small, MD on behalf of UCLA Health

Psychiatrist (Therapist)

There are genetic risks for Alzheimer’s disease. The most common gene involved is called APOE. APOE comes in three different forms. About one in five people in the population has APOE-4. This increases an individual's risk for Alzheimer's, but it's neither necessary nor sufficient to develop the disease.

Univ. of Nev. School of Medicine, Family Medicine

Genetics can play a role in your risk for certain types of Alzheimer's disease. Early onset familial Alzheimer's disease, for example, is passed on through an inherited mutated gene for the disease.

Continue Learning about Alzheimer's Disease Causes

Type 3 Diabetes: The Alzheimer’s-Glucose Connection

Alzheimer’s disease is common and mysterious, well-documented and hidden. Though it affects an estimated 5.4 million Americans (5.3 million are 65 or ...

Samuel E. Gandy, MD

Understanding how hormones such as estrogen, testosterone, and insulin impact the risk or progre...

David A. Merrill, MD

As you get older, there's about a 1% risk per year of developing Alzheimer's disease. Deficits in me...

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.

Alzheimer's Disease Causes

While much still remains a mystery about the exact cause of Alzheimer's disease, certain factors -- such as age -- present in most cases. Fifty percent of people over age 85 have Alzheimer's disease. Controllable lifestyle factors such as sleeping habits, diet choices and smoking can contribute to your risk of the disease. For more information on Alzheimer's disease, check out our experts' answers to frequently asked questions.

Learn More