How Has Technology Changed Alzheimer's Research?

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OK, well technology, going back to how we find disease genes, right, we search for variance in this human genome. It took Jim Gozel and I two years to find the first dozen variance and test them in one family, one family with [xx]. Beginning with the Alzheimer's Genome project five years ago, we tested one million DNA variance and 1000 families, in six months.

So that says it all, we're doing the same thing, but we're doing it exponentially, more comprehensively faster. And this is what we need to do, because we need to find genes, you need to start with genes on your road map to understand disease. We are not going to go there to change the genes. Some people think that you find genes and then you treat the genes, no, we leave the genes alone.

A good geneticist respects the human genome the way a sailor respects the sea. Once you think you know it, you're going to go under. Okay, and so the greatest geneticist who've been working for the longest time on the genome say, don't change the genes, OK? There's a reason why DNA is the way it is.

It's been working out its whole act for millions of you know, tens of millions, hundreds of millions of years, so leave it alone, but genes do teach you what's wrong, a gene defect leads to a protein defect, genes make protein, a protein defect leads to some biological event that goes long and that's where you can go in and say, what's my target where's my choke point?

What do I need to do? And then you find some therapy drugs or otherwise that will fix what's broken. So gene detects teacher was broken, and that's what we're doing, that's the road map, and the information needed to find out what's broken so you can fix it, has been, is coming at us now a million times faster [xx], a million times faster.