What is MUSE therapy for erectile dysfunction?

Jan L. Shifren, MD
Reproductive Endocrinology
An alternative to injections is a therapy called MUSE (which stands for "medicated urethral system for erection"). In this procedure, you use a disposable plastic applicator to insert a pellet of the drug alprostadil (the same drug that's used in injections) about an inch up the urethra. From there the drug is quickly absorbed into the erectile tissues, where it dilates the arteries.
Marc B. Garnick, MD
Hematology & Oncology
Treatment for erectile dysfunction (ED) includes Alprostadil, which is available as tiny pellets that can be inserted into the penis shortly before intercourse. These pellets are part of a therapy called medicated urethral system for erection (MUSE). This therapy involves inserting a pellet about an inch into the penis, using a disposable plastic applicator. From there, the surrounding tissue quickly absorbs the drug.

Some men find MUSE easier to use than penile injections for ED, but about 10% of men who try it find the application mildly painful, and about 3% become dizzy and develop low blood pressure. Men should not use MUSE more than twice in 24 hours.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.