How do vitamin B12 and folic acid interact with each other?

Folate and B12 are both involved in the conversion of homocysteine to methionine. A deficiency of either can lead to elevated levels of homocysteine. Also, both can lead to the development of anemia, particularly megaloblastic anemia. In these instances, it is important to determine whether the problem is a result of folate or B12 deficiency.
Both folic acid and vitamin B12 are essential for health. But when taken together, these B vitamins may interact with each other. You shouldn’t take more than 1,000 micrograms (mcg.) of supplemental folic acid per day. More than this can cause symptoms of vitamin B12 deficiency. This may lead to nervous system problems and eventually permanent nerve damage. Adults actually have a greater chance of having a vitamin B12 deficiency. Anyone 50 or older should have their doctor check their B12 levels. You should do this before taking folic acid supplements.

Dr. Michael Roizen, MD
Internal Medicine
Vitamin B12 and folate/folic acid (vitamin B9) are a collaborative, dynamic duo like Sonny and Cher. They work together to keep your body functioning properly. Along with their sidekick, vitamin C) they help with the break down, creation, and use proteins.

B12 and 9 (without their sidekick) also work together to form new red blood cells, which carry oxygen throughout the body.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.