How does Benadryl interact with other medications and foods?

Benadryl has the potential to interact with a variety of medications. It may interact with medications that are used to treat dementia and Alzheimer's disease, such as Aricept, Razadyne and Exelon. These medications and Benadryl can lessen the effects of each other. Anticholinergic drugs used for gastrointestinal problems, respiratory disease and Parkinson's disease may also interact, causing increased side effects. These include the following:

  • atropine
  • belladonna
  • benztropine
  • clidinium
  • clozapine
  • darifenacin
  • dicyclomine
  • glycopyrrolate
  • haloperidol
  • homatropine
  • hyoscyamine
  • ipratropium
  • oxybutynin
  • solifenacin
  • scopolamine
  • tiotropium
  • tolterodine

Benadryl interacts with certain monoamine oxidase inhibitors (MAOIs), such as isocarboxazid, phenelzine, rasagiline, selegiline and tranylcypromine. MAOIs and Benadryl interact by increasing side effects. There is also the potential for interaction with medications that cause drowsiness such as antipsychotic or anxiety medications, antidepressants, muscle relaxers, narcotic pain medications, sleep drugs and other antihistamines. There is a risk of developing an arrhythmia when taking Benadryl with Phenothiazine and other medications, including the following:

  • chlorpromazine
  • fluphenazine
  • perphenazine
  • prochlorperazine
  • thioridazine
  • trifluoperazine.

Pramlintide, used for treating diabetes, can also interact with Benadryl, leading to increased nausea and constipation.

Benadryl can also interact with alcohol, sedatives and tranquilizers increasing drowsiness.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.