How does glucosamine interact with other medications or foods?

Glucosamine may interact with a number of medications. Glucosamine (particularly glucosamine sulfate) may decrease the ability of acetaminophen (used to treat fever and pain) to alleviate pain. It may also cause cancer cells to become resistant to certain chemotherapy medications, such as etoposide, teniposide and doxorubicin. It may likewise interfere with the ability of diabetes medications to control blood sugar. In addition, glucosamine may exacerbate the bleeding risk in people who take medications to prevent blood clots, such as aspirin, heparin, warfarin or clopidogrel. Finally, combining glucosamine with diuretics ("water pills" such as furosemide) may exacerbate the side effects associated with glucosamine. Herbs and nutritional supplements that affect blood sugar or blood clotting mechanisms can increase the side effects of glucosamine. These include: eleuthero, fenugreek, ginger, kudzu, panax ginseng, danshen, devil's claw, garlic, gingko, horse chestnut, papain, red clover and saw palmetto. Chitosan (a nutritional supplement used for weight loss) may decrease the effectiveness of glucosamine. There are no known restrictions on food or beverage consumption while using glucosamine.

Continue Learning about Glucosamine

Can taking glucosamine sulfate supplements benefit your joint health?
Stacy Wiegman, PharmDStacy Wiegman, PharmD
Experts aren't yet sure if glucosamine sulfate supplements can benefit your joint health. Some s...
More Answers
What is the recommended dosage for glucosamine chondroitin?
Grant Cooper, MDGrant Cooper, MD
The recommended dosage for glucosamine is 1,500 mg daily; chondroitin is 800-1,200 mg daily for arth...
More Answers
Who should not take glucosamine?
Stacy Wiegman, PharmDStacy Wiegman, PharmD
Before taking glucosamine, you should speak with your healthcare provider to determine whether it is...
More Answers
What are side effects of glucosamine and chondroitin sulfate?
Scott D. Martin, MDScott D. Martin, MD
Common side effects of glucosamine and chondroitin sulfate include intestinal gas and softened s...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.