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Which hormonal therapies are most effective for breast cancer?

Recent clinical trials have demonstrated that aromatase inhibitors (AIs) are more effective than tamoxifen at reducing breast cancer recurrences in post-menopausal women, but for pre-menopausal women, tamoxifen is the treatment of choice. Many patients treated at Columbia University Medical Center have participated in national clinical trials to study these treatments and to better understand the optimal duration of their use.
Dennis L. Citrin, MD
Hematology & Oncology

The purpose of hormone therapy is to reduce estrogen stimulation for women with estrogen receptor positive breast cancer.  This can be accomplished in pre-menopausal women with the drug Tamoxifen, or with surgical removal of the ovaries.  In post-menopausal women, whose ovaries no longer produce estrogen, drugs called aromatase inhibitors are used to reduce estrogen production to a minimum.  Based on the individual patient, other hormonal therapies may also be recommended. 

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