Which medications affect the absorption of vitamin B12?

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There are several medications that can interfere with how well your body absorbs vitamin B12, possibly increasing your risk of vitamin B12 deficiency. Among the drugs that may reduce your body's level of vitamin B12 are medicines used to lower cholesterol, treat ulcers, decrease stomach acid, reduce risk of seizures and treat cancer and diabetes.

Certain antibiotics (including tetracycline), if taken at the same time as vitamin B12 supplements, may decrease your body's absorption of vitamin B12. The supplement may also decrease your body's absorption of the antibiotic, making it less effective. Taking the antibiotic and the supplement at separate times of the day may lessen these interactions. Talk to your doctor before taking vitamin B12 supplements or any dietary supplement. Always be sure that your doctor is aware of all of the medications and supplements you take.
Dr. David L. Katz, MD, MPH
Preventive Medicine

Preventive Medicine Specialist Dr. David Katz explains which medications can affect the absorption of vitamin B12. Watch Dr. Katz's video for information on preventive medicine and overall wellness.


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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.