How is osteoarthritis (OA) different from rheumatoid arthritis (RA)?

Diana Meeks
Diana Meeks on behalf of Sigma Nursing
Family Practitioner

The immune system does not play a role in osteoarthritis (OA). Unlike rheumatoid arthritis (RA), a condition that causes some symptoms similar to OA, osteoarthritis is not an autoimmune disease.

Autoimmune diseases occur when the immune system mistakenly attacks healthy cells and tissues. Osteoarthritis is a condition caused by a wearing down of the cartilage that cushions the joints. This can be the result of age-related wear and tear, injury, repetitive movements or certain genetic conditions. Both RA and OA are painful and can interfere with work and day-to-day activities.

Arthritis is an umbrella name for more than 100 diseases, including lupus, gout, osteoarthritis (OA), and rheumatoid arthritis (RA), all of which affect a person's joints or connective tissues. But OA and RA are very different diseases, with distinct symptoms and treatments:

When it starts: Later in life, usually after age 50    
Joints affected: Mostly hips, knees, feet, and spine; rarely affects hands           
Joint symptoms: Pain, swelling                                                         
Pain symmetry: No; pain often affects only one joint                               
Bone symptoms: Bony growths

Rheumatoid Arthritis
When it starts: Usually between age 30 and age 60, but can begin anytime
Joints affected: Tends to affect hands and feet first, but can affect any joints
Joint symptoms: Pain, stiffness, heat, redness, tenderness
Pain symmetry: Yes; usually occurs in joints on both sides of the body (e.g., both wrists or both ankles)
Bone symptoms: Erosion of bones in affected joints
Blood test results: Detect inflammation, anemia

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Unlike the more common osteoarthritis, which is mainly a disease of the cartilage in joints, rheumatoid arthritis (RA) occurs when the body's immune system attacks and damages the joints and, sometimes, other organs. RA often occurs in a symmetrical pattern, meaning that if one knee or hand is involved, the other one is too.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.