What are the signs of an allergic reaction to insulin?

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  A Stacy Wiegman, PharmD , Pharmacy, answered

  The most common signs of an allergic reaction to insulin will appear at the injection site soon after the insulin shot is administered. Symptoms of an allergic reaction include swelling, redness, itching and a burning sensation. In people who have an allergic reaction, the insulin usually does not work as well as it should. Less than 1% of people are allergic to insulin.
  
  If you suspect that you are allergic to your insulin, talk to your doctor. Most likely you’re having a reaction to a preservative in the insulin and not the insulin itself, so trying another brand of insulin may relieve your symptoms. In some cases, you may need to take an oral antihistamine or have a steroid added to your insulin injection.
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  A American Diabetes Association answered

  Signs of a local allergic reaction to insulin are:
  
  • dents under the skin at injection sites
  
  • redness at injection sites, either persistent or temporary
  
  • groups of small bumps, similar to hives
  
  • swelling at injection sites
  
  If you think you may be experiencing an allergic reaction to your insulin preparation, talk  to your provider.
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