What drugs and foods interact with creatine?

Some drugs and foods may interact with creatine, which is sometimes used to enhance physical performance. Creatine may harm the kidneys if taken in high doses, so be cautious if taking it along with other drugs that may also affect your kidneys. These include over-the-counter pain relievers like ibuprofen and naproxen.

There is some evidence that caffeine may reduce creatine's benefits, and there is concern about the health risks of supplements that combine creatine with caffeine and ephedra. Because creatine causes muscles to draw water from the rest of your body, it's important to drink a lot of liquids when taking it.