What drugs and foods interact with creatine?

Stacy Wiegman, PharmD
Stacy Wiegman, PharmD
Some drugs and foods may interact with creatine, which is sometimes used to enhance physical performance. Creatine may harm the kidneys if taken in high doses, so be cautious if taking it along with other drugs that may also affect your kidneys. These include over-the-counter pain relievers like ibuprofen and naproxen.

There is some evidence that caffeine may reduce creatine's benefits, and there is concern about the health risks of supplements that combine creatine with caffeine and ephedra. Because creatine causes muscles to draw water from the rest of your body, it's important to drink a lot of liquids when taking it.

Continue Learning about Dietary Supplements

Do Your Nutritional Supplements Contain the Ingredients They Say They Do?
Do Your Nutritional Supplements Contain the Ingredients They Say They Do?
Half of all US adults take dietary supplements, according to the Centers for Disease Control and Prevention, believing these pills, powders and drinks...
Read More
What are tribulus terrestris' side effects?
One possible adverse side effect of tribulus terrestris may be an increase in testosterone levels. L...
More Answers
Why aren't nutritional supplements regulated by the FDA?
The FDA does not regulate nutritional supplements because they're classified as food products, not m...
More Answers
Why are some doctors against nutritional supplements?
One of the most frustrating aspects of vitamins and supplements available is that we don't have any ...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.