This is a difficult question to answer because there are so many different conditions that can cause irritation. But as a rule of thumb, it is better to remove the contact lens. Most of the time, the contact lens is the cause of the irritation or somehow related to the irritation.
The important problems include infection, tight lens, toxicity from solutions, abrasions, and contact lens tears. These are all conditions where you should remove the lens even if the pain becomes worse with removal. Sometimes your eye doctor will insert a contact lens to treat certain ocular problems, but these lenses are different and are not cosmetic lenses.
If you have irritation with a contact lens in place, it should be removed, and if the irritation persists, you should see your eye doctor (ophthalmologist) immediately because this could be a serious problem.
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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.