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Updated on September 12, 2025
One of the most challenging aspects of managing narcolepsy can be finding the treatment or treatments that work.
Narcolepsy is a chronic neurological disorder where the brain is unable to regulate normal sleep-wake cycles. This results in excessive daytime sleepiness (EDS), “sleep attacks” during waking hours, and fragmented sleep at night. Symptoms may include cataplexy (sudden loss of muscle control), sleep hallucinations, and sleep paralysis. The condition has a significant impact on a person’s quality of life, including safety, social functioning, independence, and mental health.
People with narcolepsy will typically require medications to manage the condition. This can include medications that promote wakefulness during the day, medications that improve sleep at night, and medications that address cataplexy, for people who experience cataplexy. Lifestyle modifications, such as practicing good sleep hygiene and strategically scheduled naps, are also important to treatment.
Different therapies work for different people, and it can take time to find a treatment that works. Keeping a symptom journal or sleep diary can help you and your healthcare provider track how narcolepsy is responding to treatment and recognize when symptoms are not responding to treatment.
Is your narcolepsy treatment working?
If a narcolepsy treatment isn't working, isn't working well enough, or is not working as well as it used to, here are some things that you and your healthcare provider may want to consider:
How long you've been using this therapy
With some narcolepsy medications, it can take several weeks (and sometimes months) before you notice a significant difference in your symptoms. If you’ve been taking a medication for a short time, you may need to give it more time.
Treatment adherence
In order for a therapy to work as intended, it needs to be taken exactly as prescribed. However, adhering to a medication isn’t always easy, and it’s something that many people across many different health conditions struggle with. Missing doses or taking medications at inconsistent times can all impact how well a medication is working. If you’re having trouble adhering to a medication, be honest with your healthcare provider. Don’t think of it as a personal failing, and instead think of it as an obstacle that needs to be addressed.
External factors
Mentioned above, narcolepsy is a neurological condition where the brain is unable to regulate normal sleep-wake cycles. Sleep-wake cycles are also known as circadian rhythms, which are often described as the body’s internal clocks that follow a roughly 24-hour cycle. While circadian rhythms are an automatic process, they are also influenced by external factors. And there are many things that can influence wakefulness and sleep.
Life events, changes in schedule, nutrition, habits, disruption to routines, seasonal changes, and dozens of other factors can affect the body’s internal clocks. By extension, these factors can affect the management of narcolepsy symptoms, and these are worth discussing with your healthcare provider.
Coexisting health conditions
While narcolepsy can feel all-encompassing, it’s important to remember that it is only one aspect of your health. Many people with narcolepsy have coexisting health conditions. Common coexisting conditions include mental health disorders, metabolic disorders, and other sleep disorders, such as sleep apnea. Coexisting conditions can affect narcolepsy management, and if you’ve noticed a change in symptoms, it is worth looking at other areas of health.
Drug interactions
Medications that treat narcolepsy can interact with medications taken for other reasons, including medications for health conditions, medications for minor illnesses, and supplements. These interactions can affect how a medication works and can cause unwanted side effects. It’s important that your healthcare provider have an up-to-date list of all medications you are taking, including prescription medications, over-the-counter medications, and supplements (including things like herbal and nutritional supplements). A pharmacist can also be a valuable resource for information about drug interactions.
Alcohol and recreational drugs can also interact with medications—and are another area where it’s important to be honest with your healthcare provider. People are also advised to avoid or quit the use of nicotine, tobacco, and vaping products.
Tolerance to medication
Sometimes a medication will work well for a period of time and then work less well after more time. This is known as developing a tolerance to a medication. In some cases, a healthcare provider may recommend scheduling “drug holidays” where a person takes a break from a medication at specific times.
What are your next steps?
Your best source of information about your diagnosis and treatment options will always be your healthcare provider. If a treatment isn't working as well as you need it to, or is no longer working, your healthcare provider may recommend switching to another medication, adding a new medication, or incorporating other strategies, like lifestyle modifications. Remember that treating narcolepsy is an ongoing process that can take time and that there are multiple treatment options available.
