6 times your fatigue is something more serious

Fatigue is a state of mental and physical exhaustion that can leave you feeling weak and deflated. Temporary fatigue typically has an identifiable cause. Once it's addressed, the fatigue will go away over time. Common causes include too little sleep, a lack of exercise, or poor diet.

If your lethargy doesn’t have an identifiable cause, lasts for a long time, or isn’t remedied by restful sleep, it may be a sign of an underlying health condition, like anemia, thyroid disorders, or diabetes.

Find out what might be the source of your long-term fatigue, and whether it’s something you should discuss with a healthcare provider (HCP).

ME/CFS is a serious condition marked by extreme mental and physical exhaustion lasting at least six months. Sleep doesn’t relieve it, and symptoms often worsen after mental or physical effort. A person may also experience memory and concentration problems, muscle pain, headaches, digestive issues, and sore throat. Symptoms can intensify when a person is standing or sitting upright.

Up to 3.3 million people in the United States may have ME/CFS, according to the Centers for Disease Control and Prevention (CDC). Women are much more likely to be diagnosed than men.

The root causes of ME/CFS are still unknown, though it’s been strongly linked to certain infections, such as with Epstein-Barr virus and SARS-CoV-2 (the virus that causes COVID-19). The disorder is diagnosed using tests to rule out other conditions with similar symptoms, like sleep apnea, depression, and anemia. Many people are misdiagnosed, often with depression.

While there is no cure for ME/CFS, there is treatment available that can hep reduce symptoms. This will involve working to pace activity throughout the day so you can better conserve energy. It may also involve changing the way you handle stress, improving sleep habits, therapy, and in some cases, prescription medication.

Regardless of what you think is causing your fatigue, any periods of excessive sleepiness should be discussed with your doctor.

Heart disease is the leading killer of American men and women, responsible for 1 in 5 U.S. deaths. While some people show no symptoms, common red flags for heart attacks, heart failure, and related conditions include:

• Chest pain and tightness
• Shortness of breath
• Discomfort in other areas of the body, such as the legs, neck, jaw, or abdomen

For many—especially women—the symptoms of heart disease can also include fatigue, lightheadedness, and a hard time completing everyday tasks. It occurs because the tissues in your body don't receive enough blood from the heart.

If you experience this exhaustion, especially with other heart disease symptoms, an HCP can use stress tests, chest X-rays, blood tests, and an electrocardiogram—which measures the heart’s electrical activity—to get to the root of the problem. You can reduce your risks with medication and lifestyle changes, like eating a healthy diet and getting enough exercise.

Diabetes is a condition characterized by high glucose, or blood sugar levels. It affects more than 30 million Americans, according to the National Institute of Diabetes and Digestive and Kidney Diseases. Obesity, inactivity, and a family history of the disease all increase your risk for type 2 diabetes. Excessive thirst, frequent urination, blurred vision, unexplained weight fluctuations, and fatigue are common signs.

Diabetes causes fatigue in a lot of ways. It can happen when sugar builds up in the blood; whatever the kidneys can’t break down leaves the body in your urine. Excess urination, in turn, can lead to dehydration, which may make you tired. Hypoglycemia and fluctuations in blood sugar can also cause fatigue. Our bodies use sugar for energy, but if the body can’t process these sugars, our energy levels can drop.

If you experience fatigue along with other symptoms of diabetes, make an appointment with an HCP, who will test your urine for elevated levels of glucose and may also prescribe medication and recommend lifestyle changes.

Anemia happens when you don't have adequate red blood cells, which are responsible for carrying oxygen throughout your body. It can also occur if your body is too low in iron to produce enough hemoglobin, an iron-rich protein in your red blood cells; this is known as iron deficiency anemia. A third type of anemia, pernicious anemia, is the result of too little vitamin B12, and is common among older adults and vegetarians.

Milder cases of anemia may be symptomless, but the most common sign in severe cases is fatigue, likely caused by a lack of oxygen getting to your tissues. Other symptoms of anemia include shortness of breath, dizziness, or cold hands and feet. Iron deficiency anemia can also cause:

• Brittle nails
• Sore or smooth tongue
• Cravings for non-food items, like clay
• Pounding sensation in the ears
• Rapid heartbeat

To address your anemia, your HCP may suggest a healthy diet high in iron-rich foods like lentils, tofu, lean beef, and even dark chocolate. Other recommendations may include iron supplements and in rare cases, blood transfusions.

Treatment options for pernicious anemia include B12 shots, supplements, and a diet rich in B12. You might be advised to load your plate with foods like clams, trout, and salmon.

Located in your neck, the thyroid gland secretes hormones that affect weight, energy levels, metabolism, and the function of nearly every organ. When your thyroid is not working properly, it can produce too much (hyperthyroidism) or too little (hypothyroidism) of those necessary hormones. Both hyperthyroidism and hypothyroidism may cause fatigue, as well as weight fluctuations, changes in menstruation, and muscle aches and weakness.

If you experience fatigue along with these other symptoms, and fear a thyroid disorder may be to blame, speak with an HCP. They can diagnose thyroid conditions using your medical history, physical exams, and tests, which measure the levels of thyroid-producing substances in the body.

Fatigue is one of the most common signs of cancer, and one of the most common side effects of cancer treatment. The causes of cancer-related fatigue are somewhat unknown, but researchers believe it may be linked to toxic chemicals formed by the cancer cells in the body, or by protein and hormonal changes caused by abnormal cells.

Other general symptoms include weight loss, fever, and unexplained pain, though it can also cause localized symptoms since it affects each part of the body differently. For example, lung cancer may trigger a nagging cough, while blood in your stool or urine could signal colon or bladder cancer. If you're fatigued, look for these other red flags, which can indicate a larger problem.

Don’t wait to see an HCP if you suspect cancer is the underlying cause of your fatigue. Speedy treatment, which might include chemotherapy, radiation therapy, surgery, or any combination thereof, is important.

If you've been diagnosed already, your HCP can suggest ways to manage cancer-related fatigue. These might include an exercise regimen, short naps, a nighttime sleep schedule, a healthy diet plan, and yoga to relieve stress.