Primary syphilis usually breaks out about 3 weeks after exposure but can range from 9 to 30 days after exposure.
The chancre will last from 3 to 6 weeks and then will disappear with or without treatment. The infection will persist even when the ulcer leaves, unless antibiotics are used. The rash of secondary syphilis occurs 2 to 10 weeks after the chancre appears, often after the chancre is completely gone. The rash will disappear without treatment but often recurs. Again, the infection will persist unless antibiotics are given.
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