What are the side effects of normal saline?

Receiving normal saline can lead to fluid overload and excessive levels of sodium in the blood. Normal saline for injection can cause inflammation or irritation at the injection site. Rare side effects of this solution related to receiving too much volume include: diarrhea; cramps; nausea; vomiting; increases in heart rate, thirst, sweating, saliva, urine or tears; dizziness or lightheadedness; sleepiness; restlessness or irritability; swelling in the extremities; headaches; muscle twitching, convulsions or rigidness; or difficulty breathing.

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