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What is Yondelis?

Yondelis (trabectedin) is a drug for the treatment of certain soft-tissue sarcomas (tumors that begin in soft tissues like muscle and fat) that cannot be removed surgically. Yondelis is effective against liposarcoma and leiomyosarcoma. It is adminstered through an IV once every three weeks, following a dose of the corticosteroid dexamethasone. Yondelis has potential dangerous effects, including neutropenic sepsis, a potentially fatal loss of white blood cells; liver toxicity; rhabdomyolysis (breakdown of muscle tissue); danger to the heart; and danger to the fetus in pregnant women. Patients are closely monitored during treatment for signs of these conditions. Other side effects include nausea, vomiting, constipation, diarrhea, poor appetite, dyspnea, tiredness, breathing problems, and headache. Breastfeeding is not recommended during treatment. Safety has not been established in pediatric or elderly patients. 

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