Advertisement

What is Yondelis?

Yondelis (trabectedin) is a drug for the treatment of certain soft-tissue sarcomas (tumors that begin in soft tissues like muscle and fat) that cannot be removed surgically. Yondelis is effective against liposarcoma and leiomyosarcoma. It is adminstered through an IV once every three weeks, following a dose of the corticosteroid dexamethasone. Yondelis has potential dangerous effects, including neutropenic sepsis, a potentially fatal loss of white blood cells; liver toxicity; rhabdomyolysis (breakdown of muscle tissue); danger to the heart; and danger to the fetus in pregnant women. Patients are closely monitored during treatment for signs of these conditions. Other side effects include nausea, vomiting, constipation, diarrhea, poor appetite, dyspnea, tiredness, breathing problems, and headache. Breastfeeding is not recommended during treatment. Safety has not been established in pediatric or elderly patients. 

Continue Learning about Musculoskeletal Cancers

How is osteosarcoma diagnosed?
Jumo HealthJumo Health
To diagnose osteosarcoma, the doctors will take a close look at the bones using x-rays. Other imagin...
More Answers
How common is primary bone cancer?
Riverside Cancer Care CenterRiverside Cancer Care Center
Primary bone cancer is rare. It accounts for much less than 1 percent of all cancers. About 2,300 ne...
More Answers
Is radiation treatment effective for a chordoma?
Joshua B. Bederson, MDJoshua B. Bederson, MD
Chordomas are fairly resistant to radiation, and high doses are often needed for disease control...
More Answers
How dangerous is a chordoma?
Joshua B. Bederson, MDJoshua B. Bederson, MD
While chordomas are generally slow-growing tumors, they tend to cause local destruction of the b...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.