There appears to be a higher rate of miscarriage in women with polycystic ovarian syndrome (PCOS). The reason for this is being studied. Increased levels of luteinizing hormone, which aids in secretion of progesterone, may play a role. Increased levels of insulin and glucose may cause problems with development of the embryo. Insulin resistance and late ovulation (after day 16 of the menstrual cycle) also may reduce egg quality, which can lead to miscarriage.
The best way to prevent miscarriage in women with polycystic ovarian syndrome (PCOS) is to normalize hormone levels to improve ovulation, and normalize blood glucose and androgen levels. Recently, more doctors are prescribing the drug metformin to help with this.
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