How is active Epstein-Barr virus infection detected?

Dr. Mehmet Oz, MD
Cardiology (Cardiovascular Disease)

Tests for EBV: The only way to know for sure if an active EBV infection is the cause of fatigue is to get tested. If you have been exposed to the virus your immune system will make antibodies that the test will measure; tests measure the concentration of 6 types of EBV antibodies and the level can indicate if the infection is current or a past infection. A rising or high antibody level after at least 4 weeks of illness suggests an active infection. A positive reaction to the Monospot test indicates active mononucleosis.

There are also molecular tests that measure EBV DNA, which can help diagnose EBV-related cancers.

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