Saw palmetto may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants (blood thinners) such as warfarin (Coumadin®) or heparin, antiplatelet drugs such as clopidogrel (Plavix®), and nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®). Some batches of the discontinued combination herbal preparation PC-SPES®, which contains saw palmetto and seven other herbs, has been found to contain several medications including the blood thinner warfarin.
Saw palmetto may affect blood pressure. Caution is advised in people taking drugs that may affect blood pressure.
Early research found that saw palmetto lacks effect on cytochrome P450 1A2, 3A4, 2E1, or 2D6 activity.
Saw palmetto may also interact with agents that may affect hemoglobin levels, agents that may affect the immune system, agents that may affect the liver, agents that may lower seizure threshold, agents that may regulate heart rate, agents that may treat genitourinary tract disorders, agents that may treat impotence, agents that may treat stomach disorders, antibiotics, anticancer agents, anti-inflammatories, disulfiram (Antabuse®), and hormonal agents (such as androgens or antiandrogens).
You should read product labels, and discuss all therapies with a qualified healthcare provider. Natural Standard information does not constitute medical advice, diagnosis, or treatment.
For more information visit https://naturalmedicines.therapeuticresearch.com/