Can pancreatitis cause diabetes?
Douglas S. Denham, DO
Family Medicine

Pancreatitis is an infection or inflammation of the pancreas, an endocrine organ. It sits just behind the stomach in the abdomen and has a duct that connects to the common bile duct which empties into the duodenum. The pancreas is both an endocrine and an exocrine gland. The exocrine gland function produces enzymes that are important for digestion of proteins. These enzymes are released into the pancreatic duct and exit into the duodenum. The endocrine gland function produces the hormones, insulin and glucagon, which are important to help the body regulate blood sugars. These hormones are released directly into the blood stream to produce their actions on the body’s cells.

Pancreatitis can develop in several ways. Occasionally, gallbladder stones can get out into the common bile duct and will travel down to the junction of the common bile duct and pancreatic duct. If the stone becomes trapped in the duct it can cause the pancreatic enzymes released into the duct to back up and cause damage to the pancreas. There are also viruses that can infect the pancreas and cause inflammation and damage to the pancreas. Heavy alcohol consumption and pancreatic cancer can also cause pancreatitis. 

Treatment of pancreatitis is generally bowel rest and intravenous feeding to reduce the production of pancreatic enzymes which allows the pancreas to heal. More severe infections or frequent infections can lead to pseudo cysts, pockets of fluid in the pancreas that can affect the function of the pancreas and may require surgical excision.

If the pancreas were to become damaged severely enough that it could no longer produce insulin, then Diabetes would result. This is the mechanism that leads to the development of adult onset type I diabetes.

Farzanna S. Haffizulla, MD
Internal Medicine
 Pancreatitis is the inflammation of the pancreas which if it happens over a long time (known as chronic pancreatitis) can cause scar tissue to replace the normal functioning cells of the pancreas. Some of these cells known as Beta cells secrete insulin. If these beta cells become damaged or destroyed permanently from chronic pancreatitis then a person can develop diabetes. Insulin acts on ingested sugars and effectively acts like a "key" that opens up our cells to let the sugars in so they can be used for energy by our body. Without this "key" the sugars remain in the blood stream and damage and inflame the arteries, nerves and organs leading to many systemic complications seen wth uncontrolled diabetes.

Continue Learning about Pancreatitis


A disease of the endocrine system, pancreatitis can cause severe abdominal pain, fever and nausea and vomiting.Pancreatitis develops when the digestive juices that your pancreas makes actually begins to break down the organ itself...

. This disease, which can either be acute (short-term) or chronic (long-term), can cause internal bleeding, infection, tissue scarring and organ failure. Chronic pancreatitis actually causes the pancreas to slowly destroy itself. Gallstones that block the pancreatic duct, a tube that connects the pancreas to part of the small intestine, can cause acute pancreatitis. However, heavy alcohol use is a primary cause of both acute and chronic pancreatitis. Several days in the hospital can help resolve acute pancreatitis, but chronic pancreatitis can be much more difficult to treat, especially if the patient is an alcoholic. The surgical removal of certain nerves may be needed to relieve the severe abdominal pain associated with chronic pancreatitis.

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.