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What medications interact with antihistamine nasal sprays?

Donna Hill Howes, RN
Family Practitioner

If you are taking thalidomide, orphenadrine, or an anticholinergic drug, olopatadine can lead to side effects and should be avoided.

If you are taking eluxadoline, paraldehyde, a central nervous system depressant, or potassium chloride in solid form, azelastine and olopatadine can lead to side effects and should be avoided.

If you are taking rufinamide, topiramate, or an opioid, olopatadine may not be a good option for you.

If you are taking a selective serotonin reuptake inhibitor, azelastine and olopatadine may not be good options for you.

If you use an azelastine nasal spray, you should avoid kava kava. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.