How do antihistamines relieve cold symptoms?

Stacy Wiegman, PharmD

Pharmacy

Antihistamines are generally split into two categories: First-Generation OTC Antihistamines and Second-Generation OTC Antihistamines. First-Generation usually deals with cold and flu medications, while Second-Generation includes allergy medications. These are often combined with other drugs to control the symptoms of a cold caused by histamines. These medications compete with histamines by attaching to the histamine receptors in the body. This action stops histamines from attaching to cells and from making those cells leak fluid. In this way, antihistamines help to control congestion and drainage that are common in a cold and flu.

Continue Learning about Nasal Agent

Donna Hill Howes, RN

It is not known if cromolyn is safe or effective for children and adolescents under 18 years of age....

Lawrence T. Chiaramonte, MD

A medication like oxymetazoline hydrochloride, marketed as Afrin or Neo-Synephrine -- once avail...

RealAge

If a stuffy, blocked-up nose is your primary allergy symptom, a decongestant may offer relief. These...

Dr. Daniel R. Spogen, MD

Oral antihistamines have side effects, including dry mouth and tiredness. The most commonly used sec...

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.