What are the causes of primary sclerosing cholangitis (PSC)?

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The causes of primary sclerosing cholangitis (PSC) are not known. Genes, immune system problems, bacteria, and viruses may play roles in the development of the disease.

PSC is linked to inflammatory bowel disease (IBD). About three out of four people with PSC have a type of IBD called ulcerative colitis. The link between PSC and IBD is not yet understood.

This answer is based on source information from the National Institute of Diabetes and Digestive and Kidney Diseases.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.