What is Zollinger-Ellison syndrome?

Zollinger-Ellison Syndrome (ZES) is a condition where increased production and release of stomach acid is associated with the formation of ulcers. This is an uncommon cause of stomach and duodenal ulcers (peptic ulcers) as most are actually caused by bacteria called Helicobacter pylori (H. pylori). Most peptic ulcer disease caused by H. pylori can be treated effectively with acid reducing medications and antibiotics. ZES can be distinguished from the common cause of peptic ulcer disease in most cases, namely the presence of multiple or atypical ulcers. Atypical or multiple ulcers strongly suggest the diagnosis of ZES and therefore a gastrinoma, however in 18% to 25% of patients no ulcers are present at the time of diagnosis. 

Continue Learning about Digestive Diseases

Digestive Diseases

Digestive diseases, also known as gastrointestinal diseases, are disorders that affect your esophagus, stomach and small and large intestines. The symptoms of digestive diseases vary widely depending on which part of your digestiv...

e system is affected. Generally symptoms can be blood in your stool, a change in bowel habits, pain, weight loss or heartburn that is not relieved by antacids. See you doctor if you have any of these signs of digestive disease.

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.