What are the side effects of SGLT2 inhibitors?

Dr. Darria Long Gillespie, MD
Emergency Medicine
Side effects may include low blood pressure, dehydration, flu-like symptoms, nose and throat irritation, increased urine, urinary tract infections, nausea, constipation, high blood potassium, increased LDL cholesterol, low blood sugar, and genital fungal infections. Some people have an allergic reaction.

The FDA has warned that SGLT2 inhibitors may lead to ketoacidosis, a serious condition in which there is too much acid in the blood. The FDA has also warned that SGLT2 inhibitors can cause serious urinary tract infections that can result in blood or kidney infections. All these conditions can require hospitalization.

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Continue Learning about Diabetes


Diabetes mellitus (MEL-ih-tus), often referred to as diabetes, is characterized by high blood glucose (sugar) levels that result from the body’s inability to produce enough insulin and/or effectively utilize the insulin. Diabetes ...

is a serious, life-long condition and the sixth leading cause of death in the United States. Diabetes is a disorder of metabolism (the body's way of digesting food and converting it into energy). There are three forms of diabetes. Type 1 diabetes is an autoimmune disease that accounts for five- to 10-percent of all diagnosed cases of diabetes. Type 2 diabetes may account for 90- to 95-percent of all diagnosed cases. The third type of diabetes occurs in pregnancy and is referred to as gestational diabetes. Left untreated, gestational diabetes can cause health issues for pregnant women and their babies. People with diabetes can take preventive steps to control this disease and decrease the risk of further complications.

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