What are the side effects of SGLT2 inhibitors?

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Dr. Darria Long Gillespie, MD
Emergency Medicine
Side effects may include low blood pressure, dehydration, flu-like symptoms, nose and throat irritation, increased urine, urinary tract infections, nausea, constipation, high blood potassium, increased LDL cholesterol, low blood sugar, and genital fungal infections. Some people have an allergic reaction.

The FDA has warned that SGLT2 inhibitors may lead to ketoacidosis, a serious condition in which there is too much acid in the blood. The FDA has also warned that SGLT2 inhibitors can cause serious urinary tract infections that can result in blood or kidney infections. All these conditions can require hospitalization.

​​​​​​This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor. 

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