An indeterminate result of a thyroid nodule biopsy means that doctors cannot be certain whether a thyroid nodule is benign or cancerous. Thyroid nodules may be found to be benign (non-cancerous), cancerous or indeterminate on fine needle aspiration biopsy. Within the indeterminate category, there are additional, more specific categories that are each associated with a risk of cancer. These include atypia of undetermined significance (AUS) or follicular lesion of undetermined significance (FLUS); suspicious for follicular neoplasm (SFN) or suspicious for cancer. Indeterminate cases including AUS, FLUS and SFN, which carry a 10 to 30 percent risk of cancer, were traditionally managed with surgical removal of part of the thyroid in order to establish a definitive diagnosis. Now, molecular profile testing is available to provide additional genetic information on these nodules which may allow more patients to avoid surgery, in appropriate cases.