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Who should not take ondansetron hydrochloride?

Tell your doctor if you have the disorder phenylketonuria, because ondansetron hydrochloride contains the amino acid phenylalanine and may affect the condition. Women who are pregnant, plan to be pregnant, or breastfeeding should first consult their doctors before taking ondansetron hydrochloride because this medication is a pregnancy category B medication, which means it has not been tested in pregnant women but does not appear to harm the fetus in animal studies. It remains unclear if the drug can be passed from the mother to the infant through breast milk.  Ondansetron hydrochloride should not be taken if you are currently taking thioridazine, apomorphine, pimozide, or mesoridazine. There is a risk of increased side effects if ondansetron hydrochloride is combined with cyclophosphamide. Tell your doctor if you recently underwent abdominal surgery, as this medication could mask stomach problems. A person with liver disease may have an increased risk of side effects when taking ondansetron hydrochloride. Before taking odansetron hydrochloride tell your doctor if you are taking phenobarbital (Luminal), phenytoin (Dilantin), carbamazepin (Tegretol, Carbatrol), rifampin (Rifater, Rifadin, Rimactane), or tramadol (Ultram).  If you have allergies to 5-HT3 receptor antagonists, such as alosetron (Lotronex), granisetron (Kytril), dolasetron (Anzemet), or palnosetron (Aloxi), it may mean that you are also allergic to ondansetron hydrochloride.

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