Are there any risks in taking Zofran?

Zofran (ondansetron), a prescription medication for nausea, can be dangerous for some people. That includes anyone who is allergic to the active ingredient, ondansetron. It may affect your heart rate, and can be dangerous for people with a family history of “Long QT” syndrome, a heart condition. It may also pose risks for people with liver disease and a genetic condition called PKU. Zofran is often given as quick-dissolving tablets that you place on your tongue. It works very quickly to stop nausea triggered by chemotherapy or radiation.  Zofran may also have serious side effects which require immediate medical help such as vision loss or temporary blindness (for a few minutes up to a few hours); a slow heartbeat; trouble breathing; anxiety, agitation or shivering; feeling like you might pass out; urinating less than normal, or not at all; an allergic reaction causing trouble breathing or swelling of the face, tongue, lips or throat. Zofran may also make you drowsy or dizzy, so make sure you are alert enough to drive. When Zofran is taken with other medications that increase levels of a brain chemical called serotonin, there is a risk of a serious condition called serotonin syndrome. Symptoms of serotonin syndrome include agitation, hallucinations, rapid heart rate, dizziness, tremor, seizures, nausea and vomiting. 

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