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What medications or supplements interact with amitriptyline?

Donna Hill Howes, RN
Family Practitioner

If you are taking a 5-HT3 antagonist, an antipsychotic, lithium, metaxalone, methylphenidate, metoclopramide, mirabegron, orphenadrine, tedizolid, or a drug that prolongs the QTc interval, amitriptyline can lead to serious side effects and should be avoided.

If you are taking abiraterone, an anticholinergic bronchodilator, azelastine nasal spray, cisapride, dronedarone, eluxadoline, iobenguane I-123, linezolid, panobinostat, paraldehyde, a selective serotonin reuptake inhibitor, a serotonin and norepinephrine reuptake inhibitor, or thalidomide, amitriptyline can lead to side effects and should be avoided.

If you are taking an anticholinergic drug or rufinamide, amitriptyline may not be a good option for you.

If you are taking tramadol, amitriptyline can lead to serious side effects. Other opioids may also not be good options for you. 

If you are taking potassium chloride in solid form, amitriptyline can lead to side effects and should be avoided.

If you are taking an MAO inhibitor, amitriptyline can lead to serious side effects.

If you take amitriptyline, you should avoid St. John's wort and kava kava.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.