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Is PreserVision for macular degeneration safe to take with warfarin?

Anthony L. Komaroff, MD
Internal Medicine
PreserVision is a combination of vitamins and minerals that may help prevent early macular degeneration from progressing to an advanced form of the disease. A daily dose of PreserVision contains 28,640 international units (IU) of vitamin A (572% of the recommended daily value [DV]), 452 mg of vitamin C (754% DV), 400 IU of vitamin E (1,334% DV), 69.6 mg of zinc (464% DV), and 1.6 mg of copper (80% DV).

High doses of vitamin E act a bit like warfarin (Coumadin) -- both make it more difficult for blood clots to form. This doesn't mean you shouldn't take PreserVision. Instead, it means you should alert the doctor, nurse, or pharmacist who monitors your warfarin that you will be starting this supplement. Extra checks of your international normalized ratio (INR) may not be much help, since this test detects only a small amount of vitamin E's anticoagulant action. Instead, be alert for signs of a bleeding problem, such as a cut that won't stop bleeding, a large bruise that keeps on growing, an increase in the number of bruises you are experiencing, or more bleeding than usual when brushing your teeth.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.