Anticoagulant

Anticoagulant

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    The manufacturer of this drug has withdrawn it from the market, and it is not currently available.

    Drotrecogin alfa is a recombinant form of human activated protein C, a natural anticoagulant enzyme with potent anti-clot and anti-inflammatory properties. It is administered to hospitalized adults with severe sepsis and multiple organ system failures to decrease the mortality rate. Sepsis is a bacterial infection in the bloodstream that affects the whole body by causing inflamation and clot formation in various organs. Drotrecogin alpha works by decreasing the production of inflammatory chemicals, preventing clot formation and increasing clot breakdown. This drug is given slowly by continuous intravenous infusion and may take as long as four days to administer.  Drotrecogin alfa is available only under the brand name Xigris.

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    Dalteparin is the name of the active ingredient in a drug sold under the brand name Fragmin. It is an injectable anticoagulant; it prevents dangerous blood clots from forming. In other words, this is a drug that "thins the blood." Dalteparin is often taken with aspirin. This combination prevents clotting problems in blood vessels. It’s effective for treating deep vein thrombosis. This is a serious blood clot that can occur after surgery, when someone is bed-ridden for a long-term illness, or is sitting and not mobile during long car rides or plane flights. It also treats heart attacks and angina (chest pain).

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    Fragmin is the brand name of dalteparin. It is an anticoagulant, which prevents dangerous blood clots by thinning the blood. Dalteparin is often taken with aspirin to prevent blood vessel complications in patients with angina (chest pain) or heart attacks. Dalteparin is also used to prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism). A DVT can occur after certain types of surgery, or in people who are bedridden due to a long-term illness. Dalteparin is also used long term to treat a blood clot called a venous thromboembolism.

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    Dalteparin may cause a number of side effects. Get emergency medical attention if you experience signs of an allergic reaction, such as hives, itchy skin rash, difficulty breathing or swelling of the face, tongue or throat. Discontinue treatment and talk to your doctor as soon as possible if you experience any of the following severe side effects: easy bruising or bleeding that will not stop; bloody, black or tarry stools; pink or red urine; difficulty walking; severe or persistent dizziness or fainting; numbness or tingling in the feet or legs; muscle weakness; red or brown vomit that resembles coffee grounds; unusually heavy menstrual periods; or feverish symptoms.

    Dalteparin also may cause more common side effects that do not require medical attention unless they worsen or persist. Call your doctor if the following mild side effects become bothersome: pain, swelling, redness at the injection site or upset stomach. During dalteparin treatment, tell your doctor if you experience any side effects that are not listed here.

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    Dalteparin is a type of medication called an anticoagulant or blood thinner. It prevents the formation of blood clots in people who have had certain surgeries, chest pains (angina) or heart attacks. It can prevent a condition called deep vein thrombosis (DVT), in which a blood clot forms in the large veins of the legs after surgery. By preventing DVT, dalteparin reduces a person's risk of a life-threatening pulmonary embolism, in which a blood clot travels to the lungs and damages lung tissue.

    Dalteparin treatment also can benefit people with cancer who are at a higher risk of developing a type of blood clot called venous thromboembolism (VTE). Dalteparin can be categorized as a low molecular weight heparin. While it cannot dissolve an existing blood clot, dalteparin can prevent an existing clot from getting larger, as well as preventing new blood clots from forming. Dalteparin is administered intravenously and is often paired with other medications such as aspirin. The brand name of dalteparin is Fragmin.

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    You should not receive dalteparin if you are allergic to pork products, heparin, benzyl alcohol, enoxaparin or any of the ingredients listed on the prescription label. Dalteparin is not for people with severe high blood pressure, excessive bleeding or a personal history of low platelet levels or other complications due to heparin treatment. If you are prescribed dalteparin to treat chest pain or a heart attack, do not use it if you are also scheduled to receive local anesthesia. Because little is known about its effects on children, use extreme caution when administering dalteparin to children.

    Talk to your doctor about the risks and benefits of receiving dalteparin during pregnancy. Dalteparin contains benzyl alcohol that can harm a fetus, and pregnant women who decide to receive dalteparin must be prescribed a version of dalteparin without this added preservative. Check with your doctor if you are breastfeeding during dalteparin treatment, as it can pass to your baby through breast milk. Dalteparin should be used with caution in elderly people, as they may experience more severe side effects. Also, it is important to avoid activities that may cause injury or bodily damage during dalteparin treatment.

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    Like most other anticoagulants, an injection of dalteparin can interact with a variety of other medications. It is crucial to tell your doctor if you are taking any of the following medications before you begin dalteparin treatment: dipyridamole; direct factor Xa inhibitors; direct thrombin inhibitors; drugs that affect platelets, such as aspirin, clopidogrel or ticlopidine; NSAIDs (nonsteroidal anti-inflammatory drugs), such as ibuprofen or naproxen; nitrates, such as nitroglycerin; other anticoagulants, such as warfarin or activated protein C; salicylates, such as aspirin; sulfinpyrazone; or thrombolytics, such as streptokinase. Dalteparin may interact with medications not on this list.

    Before you begin treatment, tell your doctor about any herbal or dietary supplements, vitamins or minerals you take. Also, tell your doctor if you smoke, drink alcohol or take illegal drugs, as they may also affect the safety and quality of your treatment. If you need to start taking another medication while you are being treated with dalteparin, consult with your doctor first. Dalteparin may cause adverse reactions in people who are allergic to pork products, heparin, benzyl alcohol or enoxaparin.

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    Before beginning dalteparin treatment, tell your doctor if you are allergic to pork products, benzyl alcohol, heparin or enoxaparin (Lovenox), or if you have any medical conditions, such as a history of kidney, liver, stomach or intestinal problems (including ulcers). Also, inform your doctor if you have uncontrolled diabetes or high blood pressure (e.g. vision problems); a personal or family history of stroke, bleeding disorders or bleeding in the brain; von Wildebrand disease; inflammation of the heart due to a bacterial infection; or if you have recently had or are planning any of the following surgical procedures--an epidural catheter, a spinal puncture or surgery of the brain, spine or eye.

    If you are pregnant, breastfeeding or wish to become pregnant, talk to your doctor about dalteparin. Tell your doctor about all medications you are taking before you start any anticoagulant treatment, as they may interact with each other. Do not start taking another medication during dalteparin treatment without first consulting with your doctor.

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    Enoxaparin injection is a generic version of the prescription drug Lovenox. It is used to both prevent and treat blood clots. You may be given an enoxaparin injection to keep you from developing a dangerous blood clot if you are undergoing abdominal, hip or knee surgery. In this case, you will be injected with enoxaparin two hours before surgery. If you already have a blood clot in your lungs or veins, your doctor may use this medication as part of your treatment. Enoxaparin injection is an anticoagulant medication.

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    Side effects of Innohep can occur. Discomfort at the injection site is common, and need only be reported to your doctor if it is severe or if it is accompanied by bleeding. More serious side effects are possible and you should contact your doctor right away if you experience them. These include symptoms of an allergic reaction to Innohep, including severe itching, a rash or hives, swelling of the face or mouth and trouble breathing. Other serious side effects include:

    • faintness
    • dizziness
    • lightheadedness
    • fever
    • headaches
    • constipation
    • nausea and vomiting
    • chest pain
    • urinary tract infection
    • unusually heavy menstrual flow

    Since this drug can cause bleeding, be aware of side effects that would indicate bleeding problems, such as:

    • nosebleeds
    • bruising
    • bleeding gums
    • red skin spots
    • black stools
    • coughing blood
    • bloody urine
    • back and stomach pain