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What are the side effects of hydrocodone and acetaminophen?

Common side effects of hydrocodone-acetaminophen include: dizziness, lightheadedness, drowsiness or sedation and nausea and vomiting, belching; mood swings; loss of appetite; constipation; fear or nervousness; and indigestion. If these persist, call your doctor.

Other less common and more serious side effects that need medical attention include: hearing loss; difficulty hearing; back pains; leg pains; stomach pains; black, tarry stools; bleeding gums; blue lips or skin; fever or chills; choking, cough or hoarseness; dark urine, decreased urine output or frequency, difficult or painful urination; dizziness; rapid heartbeat; edema; tiredness or weakness; headaches; light-colored stools; nosebleeds; pale or bluish fingernails; pinpoint red spots on the skin; unable to speak; unusual bleeding or bruising; upper right abdominal or pain; wheezing; and yellow eyes and skin (jaundice).

Sympoms of allergic reactions may include: hives, itching; difficulty breathing; puffiness or swelling of the eyelids or around the eyes, face, lips or tongue; tightness in the chest; and difficulty swallowing. An allergic reaction is a medical emergency.

An overdose can occur with this medication if prescribed doses are not followed. Contact your doctor immediately if any symptoms of overdose appear. They include: bloody or cloudy urine; lapsing of consciousness; chest pain or discomfort; cold and clammy skin; decreased awareness or responsiveness; general discomfort or feeling of illness; increased sweating; slow or irregular heartbeat; lightheadedness; dizziness or fainting; sudden decrease in urine output; unpleasant breath odor; or vomiting blood.