How does oxycodone and acetaminophen interact with other drugs or food?

Central nervous system (CNS) depressants (drugs that make you drowsy, sometimes referred to as sedatives and tranquilizers) can increase the effects of oxycodone and acetaminophen. These medications include: antihistamines and drugs for allergies or colds, sedatives, other prescription pain medicine or narcotics, medicine for seizures, muscle relaxants or anesthetics. There may be a risk of liver damage if you have three or more alcoholic beverages while taking acetaminophen.
Before you take oxycodone and acetaminophen, tell your doctor if you are taking glycopyrrolate (Robinul), mepenzolate (Cantil), atropine, benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine) or scopolamine (Transderm-Scop). Also tell your doctor if you are taking any bladder or urinary medications, such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol) or solifenacin (Vesicare). Talk with your doctor about using a bronchodilator, such as ipratropium (Atrovent) or tiotropium (Spiriva) with oxycodone and acetaminophen. If you take medications for irritable bowel syndrome, such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin and others) or propantheline (Probanthine), you should let your doctor know.
Tell your doctor about any other drugs or supplements that you take. This includes vitamins, minerals, herbal remedies and over-the-counter medications.

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