Can acetaminophen-butalbital-caffeine interact with other drugs?

Yes, each active ingredient in this three drug combination can interact with other drugs. Therefore, tell your doctor and pharmacist about all prescription and nonprescription medications you are taking. Be sure to mention the following: anticoagulants (blood thinners) such as warfarin (Coumadin), antidepressants, antihistamines, pain medications, sedatives, sleeping pills, tranquilizers and vitamins. Many nonprescription pain relievers and cold medicine combinations contain acetaminophen. Read the labels carefully because too much acetominophen can be liver damage.