Does vitamin B9 interact with any drugs, foods or other supplements?

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Yes. The following list of moderate possible interactions from MedLine should help:

5-Fluorouracil
  • Taking large amounts of folic acid with 5-fluorouracil might increase some side effects of 5-fluorouracil, especially stomach problems.
Capecitabine (Xeloda)
  • There is some concern that taking large amounts of folic acid might increase the side effects of capecitabine, especially stomach problems like diarrhea and vomiting.
Fosphenytoin (Cerebyx)
  • Fosphenytoin (Cerebyx) is used for seizures. The body breaks down fosphenytoin (Cerebyx) to get rid of it. Folic acid can increase how quickly the body breaks down fosphenytoin (Cerebyx). Taking folic acid along with fosphenytoin (Cerebyx) might decrease the effectiveness of fosphenytoin (Cerebyx) for preventing seizures.
Methotrexate (MTX, Rheumatrex)
  • Methotrexate (MTX, Rheumatrex) works by decreasing the effects of folic acid in the body's cells. Taking folic acid pills along with methotrexate might decrease the effectiveness of the drug.
Phenobarbital (Luminal)
  • Phenobarbital (Luminal) is used for seizures. Taking folic acid can decrease how well phenobarbital (Luminal) works for preventing seizures.
Phenytoin (Dilantin)
  • Used for seizures. Folic acid might increase how quickly the body breaks down phenytoin (Dilantin). Taking folic acid and phenytoin (Dilantin) might decrease the effectiveness of the drug and increase the possibility of seizures.
Primidone (Mysoline)
  • Primidone (Mysoline) is used for seizures. Taking folic acid along with primidone (Mysoline) might decrease how well primidone works for preventing seizures.
Pyrimethamine (Daraprim)
  • Pyrimethamine (Daraprim) is used to treat parasite infections. Folic acid might decrease the effectiveness of pyrimethamine (Daraprim) for treating parasite infections.
When under the care of a physician for any medical issue, it is recommended that you check with them prior to adding or using any dietary supplements.
Vitamin B9 (folic acid) may interact with phenytoin, primidone, methotrexate, barbiturates, nitrofurantoin, tetracycline and pyrimethamine. You should talk to your doctor if you are using any of these medications and want to take a folic acid supplement. You may need to alter either your dosage or the times at which you take the drugs. Discuss regular alcohol use with your doctor before beginning B9 therapy, since alcohol lowers the absorption of the vitamin.
 

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.