Are there any risks in taking pyridoxine?

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As with any medication, there can be risks in taking vitamin B6 (also known as pyridoxine). However, the risks are generally small. It is possible to have an allergic reaction or a drug interaction with vitamin B6 and another medication or supplement. It is also possible to overdose on it, which can cause numbness and clumsiness. If you are getting enough vitamin B6 through your diet or other B multivitamins, you should not take pyridoxine. Pyridoxine is generally considered safe during pregnancy and may be recommended to help with nausea during pregnancy.