How does tramadol interact with other medications or food?

Donna Hill Howes, RN
Family Practitioner

If you are taking/using...

  • An anticholinergic drug, a diuretic, metoclopramide, or rufinamide - Tramadol may not be a good option for you
  • Linezolid, metaxalone, tedizolid, an antipsychotic drug, an opioid, a selective serotonin reuptake inhibitor (SSRI), or a serotonin-NE reuptake inhibitor (SNRI) - Tramadol can lead to serious side effects
  • Azelastine nasal spray, carbamazepine, dabrafenib, eluxadoline, orphenadrine, paraldehyde, or thalidomide - Tramadol can lead to side effects and should be avoided
  • An MAO inhibitor or have taken one in the past few weeks - Tramadol can lead to serious side effects.

If you take tramadol, you should avoid St. John's wort and kava kava. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.