What are the side effects of syphilis treatment?

Penicillin is the most common treatment for syphilis, and it can cause side effects in some people. Up to half of the people who are treated with penicillin develop a reaction to the injection within just a few hours. This reaction is called the Jarisch-Herxheimer reaction and can cause symptoms like fever, chills, and headache. Usually, these symptoms don't last more than 24 hours, but talk to your doctor if you notice any worrisome symptoms after being treated for syphilis.

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