How does hydroxyzine hydrochloride (HCl) interact with other medications?

Hydroxyzine may interact with certain medications, including non-narcotic analgesics like ibuprofen and acetaminophen; barbiturates like secobarbital and phenobarbital; and narcotics such as meperidine or oxycodone. In addition, hydroxyzine hydrochloride may intensify the effects of alcohol, so alcohol consumption should be avoided. Let your doctor know of any medications you are taking before starting hydroxyzine hydrochloride, and don't start any new medications before consulting with your doctor.