Can Kalydeco interact with other medications or foods?

Kalydeco (ivacaftor), a prescription drug to treat cystic fibrosis, can interact with other medications, supplements and foods. Grapefruit, grapefruit juice and Seville oranges can affect how your body metabolizes Kalydeco. You should not take certain medications with Kalydeco, including the antibiotics rifampin and rifabutin, the seizure medications phenobarbital, carbamazepine and phenytoin or the herbal supplement St. John’s wort.

Other medications that can interact with Kalydeco include antifungal medications (ketoconazole, itraconazole, posaconazole, voriconazole, fluconazole), seizure medications, certain antibiotics (telithromycin, ciprofloxacin, clarithromycin, erythromycin) and others. Talk to your doctor about any medications or supplements you take, to find out if you need to make a change before you start taking Kalydeco.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.