What are the side effects of norethindrone (Aygestin)?

Norethindrone can cause a variety of side effects, some of which can be serious. Though relatively uncommon, you should call 911 for emergency medical help if you experience any of these symptoms while taking this drug: allergic reaction, including breathing difficulty, chest tightness, hives, rash, itching or swelling in your face, mouth, lips, tongue, or throat; chest pain or heaviness; shortness of breath; coughing up blood; sudden or severe headache, including migraine; vision changes, including blurred vision, double vision, loss of vision, or bulging eyes; speech problems, including slurred speech or slow and difficult speech; sudden loss of coordination or clumsiness; severe dizziness; fainting; vomiting; swelling of the arms, hands, fingers, lower legs, or ankles; pain, tenderness, heaviness, or a warm sensation, in the calves; pain, weakness, or numbness in your legs or arms; yellowing of the eyes or skin; brown facial patches and sudden and severe abdominal pain.

Contact your doctor if you experience any or the following symptoms while taking norethindrone: depression; mood swings; lumps in your breasts or under your armpits; or missed menstrual periods.

Less serious side effects include: changes in your menstrual flow; irregular vaginal bleeding or spotting between menstrual periods; hot flashes; tender or enlarged breasts; nausea; drowsiness; mild dizziness; mild pain, including stomach pain; mild rash; weight changes; fever; weakness; mild headache; nervousness; sleeping problems, such as having trouble falling asleep or staying asleep; acne; and facial hair growth.

You should talk to your doctor if any of these side effects are severe or long-lasting.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.