What should I know about progesterone injection before using it?

There are certain precautions you should be aware of before getting a progesterone injection. It may cause harmful reactions if you have a history of certain medical conditions, including liver, heart or kidney disease, breast cancer, blood clots, stroke, asthma, seizures, depression, unexplained vaginal bleeding, bleeding on the brain, diabetes or high cholesterol. Similarly, progesterone may interact poorly with certain medications, such as St. John's wort, anti-seizure medicines like carbamazepine, antifungal medicines like itraconazole and antibiotics like rifabutin. If you are pregnant or breastfeeding, you should alert your doctor, as progesterone may cause damage to your child's health. Also, be aware that progesterone may cause serious side effects, ranging from difficulty urinating and jaundice (yellowing of skin and eyes) to breast lumps and depression. Finally, you should know that progesterone may affect the results of certain lab tests, so let your doctor or lab technicians know that you are using it before you undergo any testing.