What should I know about progesterone before using it?

When used in combination with estrogen as part of hormone replacement therapy, progesterone can increase your risk of blood clots, pulmonary embolism, stroke and heart attack.

It can also increase the risk of ovarian cancer, deep vein thrombosis and dementia.

The increased risk is correlated with the duration of use and amount of estrogen used. To minimize these increased risks, you should use the lowest possible dose for the shortest amount of time possible.

You should not use progesterone if you have heart or blood problems, a history of breast, ovarian, cervical or vaginal cancer or have liver disease.

Do not use progesterone if you are pregnant or are allergic to progesterone or peanuts, since the synthetic hormone contains peanut oil.

You should talk to your doctor about possible risks if you are overweight, have a history of seizures, depression or mental illness or smoke.

Diabetes patients should know that progesterone may raise blood sugar levels. Some medications, like rifampin, may decrease progesterone's effectiveness.

Continue Learning about Progesterone

Where does progesterone come from?
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While it is pretty unlikely, it is possible to be allergic to progesterone. In the rare cases that a...
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Does progesterone cause blood clots?
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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.