Can prednisone interact with other medications or foods?

Prednisone is not known to interact with foods, but if you drink alcohol when taking this steroid medicine over a long period of time, it could raise your risk of stomach ulcers and bleeding in the digestive tract. Prednisone can increase fluid retention, so ask your doctor if you should be on a low-sodium diet. Prednisone can also make your body eliminate too much potassium and calcium, so your doctor may suggest supplementing your diet with these nutrients.
Prednisone can interact with many other medications, including:
  • antacids
  • birth control pills
  • thyroid medicines
  • macrolide antibiotics (erythromycin, clarithromycin, azithromycin, troleandomycin)
  • ephedrine
  • rifampin
  • antiseizure medications
  • antifungal medications
  • antidepressants (including tricyclic antidepressants)
  • medicines for human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) 
  • blood thinners, such as warfarin
  • heart medicines
  • acetaminophen
  • nonsteroidal anti-inflammatory drugs (NSAIDs)
  • diuretics
  • cyclosporine
  • aprepitant
  • lovastatin
  • rifabutin
  • zafirlukast
  • asparaginase 
  • other corticosteroids, such as dexamethasone
Prednisone may increase your blood sugar levels, so if you take diabetes medicines, they may not work as well while taking it. Be sure your doctor knows about any other drugs and dietary supplements you take, especially St. John's wort. Do not take any new medicine or supplement without talking to your doctor first.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.