What should I know about Prepopik before taking it?

Before taking the pre-colonoscopy laxative Prepopik (sodium picosulfate, magnesium oxide and citric acid), you should know whether you are allergic to sodium picosulfate, magnesium oxide or citric acid, the active ingredients in this drug.

You should also know that having certain medical conditions increases your risks for serious side effects from this medication. Be sure to give your doctor a complete medical history before taking Prepopik. In particular, let your doctor know if you have recently stopped drinking alcohol or taking benzodiazepines, or if you have any of the following conditions:
  • dehydration
  • difficulty swallowing or reflux
  • heart disease
  • high or low blood levels of calcium, magnesium, potassium or sodium
  • history of irregular heartbeat
  • impaired kidney function or kidney disease
  • seizures
  • problems with your stomach or intestines
  • bowel obstruction or perforation
  • gastrointestinal obstruction or gastric retention
  • ulcerative colitis, toxic colitis or megacolon
You should know that certain medications and supplements may interact with Prepopik and increase your risks for side effects or decrease the drug’s effectiveness. Prepopik may also reduce the effectiveness of other medications. Be sure to tell your doctor about all the medicines (prescription and nonprescription) and dietary supplements you take, especially the following:
  • carbamazepine (Tegretol)
  • some medicines for blood pressure, heart disease or irregular heartbeat
  • some medicines for depression, anxiety or psychotic disturbances
  • diuretics
  • nonsteroidal anti-inflammatory drugs (NSAIDS), such as ibuprofen or naproxen
  • steroid drugs such as prednisone or cortisone
  • theophylline (Theochron) or aminophylline
  • tramadol (Ultram)
Tell your doctor if you are pregnant or breastfeeding. It is unknown whether Prepopik can harm a developing fetus or pass into breast milk. Your doctor can help you decide whether you should take this drug if you're pregnant or breastfeeding.

You should not take other laxatives while using Prepopik. Consuming plenty of clear liquids is important to prevent dehydration. Follow patient instructions carefully.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.