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Can I use Roxicodone if I am taking a CYP3A4 inhibitor?

The package insert for the prescription pain medication Roxicodone (oxycodone) doesn't warn users to avoid CYP3A4 inhibitors -- drugs or other substances that interfere with a specific enzyme (called CYP3A4) needed to break down some medications. However, some laboratory evidence suggests that certain CYP3A4 inhibitors may affect how your body processes Roxicodone. If Roxicodone isn't broken down the way it should be, your blood level could climb high enough to be dangerous.

A 2012 laboratory study found that the antifungal drug ketoconazole -- which is known to inhibit CYP3A4 enzymes -- slowed the breakdown of oxycodone, the active ingredient in Roxicodone. Still, this was a laboratory study -- it's not clear whether the same thing would happen in humans. To be on the safe side, tell your doctor about all prescription and over-the-counter medications you take, including herbal remedies and dietary supplements, before you start Roxicodone.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.