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What medications interact with opioids?

Donna Hill Howes, RN
Family Practitioner

If you are taking a benzodiazepine, mifepristone, or sodium oxybate, you should not take opioids.

If you are taking acyclovir, meperidine may not be a good option for you. 

If you are taking carbamazepine, tramadol can lead to side effects and should be avoided.

If you are taking an anticholinergic drug, an azole antifungal drug, cimetidine, a CYP3A4 inducer, perampanel, or a phenothiazine, an opioid may not be a good option for you.

If you are taking amiodarone, a drug that prolongs the QTc interval, a selective serotonin reuptake inhibitor, or tricyclic antidepressant, opioids can lead to serious side effects.

If you are taking a protease inhibitor, meperidine can lead to side effects and should be avoided.

You should not take an opioid while taking MAO inhibitors or until at least 2 weeks after stopping MAO inhibitors. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor. 

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.