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Does methadone oral concentrate interact with other medications?

Many medications can interact with methadone hydrochloride oral concentrate. Medications that may make methadone hydrochloride oral concentrate less effective include: abacavir, carbamazepine, efavirenz, HIV protease inhibitors, narcotic agonists/antagonists, nevirapine, phenobarbital, phenytoin, rifampin, and St. John's wort.

Methadone hydrochloride oral concentrate may decrease the effectiveness of antiretroviral agents such as stavudine.

Side effects may be increased if methadone hydrochloride oral concentrate is taken with barbiturates, benzodiazepines, cimetidine, zivovudine, narcotic analgesics, phenothiazines, azole antifungals, or serotonin selective reuptake inhibitors (SSRIs).

The following drugs can cause increased risk of QT prolongation if taken with methadone hydrochloride oral concentrate: antiarrhythmics, antipsychotics, calcium channel blockers, antiemetics, chloroquine, diuretics, H1 antagonists, kinase inhibitors, lithium, macrolide antibiotics, phenothiazines, quinolones, streptogramins, tacrolimus, and tricyclic antidepressants. In addition, alcohol can increase the risk of slowed breathing when combined with methadone hydrochloride oral concentrate. You should avoid drinking alcohol and make sure that no foods you eat contain alcohol.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.