Treximet tablets, active ingredients of sumatriptan and naproxen sodium, can cause minor side effects including gastrointestinal upset like nausea, constipation or diarrhea. Some people experience heart palpitations, dizziness or unusual sensations, like muscle tightness, heat or tingling on the skin.
Naproxen is a non-steroidal anti-inflammatory drug (NSAID), which can cause more severe side effects in some people. These can include an allergic reaction, which could cause hives, trouble breathing or swollen tongue or mouth.
Other severe side effects to watch out for include chest pain or trouble breathing. These are medical emergencies. Call 911. Other serious side effects include: black, tarry stool; dark, grainy or bloody vomit; reduced urination; pale stool; swelling or sudden weight gain; yellowing around the eyes; confusion or depression; severe flushing; cold or blue toes and fingers; slurred or distorted speech; loss or distortion of vision; flu-like symptoms; jaw or neck pain; swelling in your extremities; unusual weakness, tiredness, bruising or bleeding; numbness or one-sided weakness; or wheezing. Call a doctor immediately if you have any of these symptoms.